A Diversity-Oriented Strategy for the Construction of Tetrasubstituted Pyrroles via Coupled Domino Processes
نویسندگان
چکیده
منابع مشابه
A diversity-oriented strategy for the construction of tetrasubstituted pyrroles via coupled domino processes.
A new microwave-assisted rearrangement of 1,3-oxazolidines scaffolds is the basis for a new, metal-free, direct, and modular construction of tetrasubstituted pyrroles from terminal-conjugated alkynes, aldehydes, and primary amines. This new reaction manifold entails two linked domino processes in a one-pot manner with both atom- and bond-efficiency and under very simple and environment-friendly...
متن کاملMulticomponent domino processes based on the organocatalytic generation of conjugated acetylides: efficient synthetic manifolds for diversity-oriented molecular construction.
The organocatalytic generation of a strong base by the action of a good nucleophile is the base for the in situ catalytic generation of conjugated acetylides in the presence of aldehydes or activated ketones. The method is affordable in a multicomponent, domino format able to generate a chemically diverse set of multifunctionalized adducts that are very well suited for diversity-oriented molecu...
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چکیده ندارد.
15 صفحه اولFrom conjugated tertiary skipped diynes to chain-functionalized tetrasubstituted pyrroles.
Among the most appreciated chemical complexity-generating reactions, domino processes [1] maintain a privileged status. They perform molecular complexity in a fast and efficient manner, accumulating important “green chemistry” values such as atom, time and labour economies, resource management and minimal chemical waste generation. An appealing subclass of domino processes comprises the reactio...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2004
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja047396p